April 14, 1994 Maggie — I finished reading the draft last night. I've been trying to figure out how to respond since about page 9, which is where I realized this wasn't going to be the paper I expected. Here's the honest version: The first half is excellent. Sections 1 through 3 are the best work you've done. The phenotype description is careful, the heritability data is solid, the epigenetic framework is exactly right for where the field is going. I would have signed my name to any of that. Section 4 is where I start to lose you. Not because you're wrong — I don't think you're wrong — but because you've stopped distinguishing between what you know and what you suspect. The paragraph about the researcher who calls it the "quiet switch" and won't publish — that paragraph is doing a lot of work in the narrative and it's doing it without evidence. You're asking the reader to trust your pattern recognition. Some readers will. The reviewers at JDNBG will not. Section 5 is where I have to be direct with you. The personal disclosure is not a small thing. I understand why you're including it. I think, knowing you, that you've been waiting years to include it, and that this paper finally gave you a container for it. I'm not going to tell you it's wrong to include it. But I need you to understand what it will do to the reception of everything that comes before it. The moment you say "I was in one of these programs," the paper stops being a scientific argument and becomes a personal one. It doesn't matter how careful you've been. It doesn't matter how good the data is. The reviewers will have a different question in front of them, and it's not the question you want them asking. The part that concerns me most isn't the disclosure itself. It's the footnote. Footnote 9. "The author is aware that the previous sentence would not survive peer review. She is leaving it." Maggie. You can't submit that. I know why you wrote it. I know what it feels like to have a finding that the field isn't ready for and to be told to wait and to keep waiting while the thing you found keeps existing regardless of whether anyone believes you. I've been there. You've been there. That's not new. But this is different. The things you're describing — if they're what you think they are — the people who know about them are not going to be neutralized by a journal article. Publishing this as written doesn't protect you. It just tells them you know. I don't know what telling them you know does. I've been trying to think about it for three days and I don't have a good answer. Call me before you submit this. Please. Your friend and colleague, T.J. Kessler Dept. of Molecular Genetics Harwick Institute P.S. The footnote about the unverifiable source in the References — "one source the author is not citing because she does not know its provenance and is not certain it is real" — I assume you know what you're doing with that. I hope you know what you're doing.